Until recently, medical science knew very little about the endocannabinoid system and how Cannabidiol (CBD) and THC attach themselves to brain receptors to carry out their effects in the body. There are at least two receptors that interact with cannabis compounds to generate the effects we’ve gotten used to. THC attaches to CB1 receptors to generate the euphoric feeling that marijuana is known for, and CBD, which contains no psychoactive ingredient, attaches to CB2 receptors, and among other things, it counteracts the effects of CB1 receptors and assists the body in managing pain.
When used as treatment for pain, CBD has a powerful effect on neuropathic pain, which is pain of the nerves and might be caused by peripheral nerve injury or other factors. By activating CB2 receptors, CBD activates many of the pathways that ease pain, and this goes a long way towards managing long term conditions such as diabetes, MS, and fibromyalgia.
Some research suggests that CBD also eases pain by engaging glycerin receptors – which are part of the central nervous system and are in different parts of the brain and spinal cord. If a person has chronic pain, inflammatory factors sometimes disable these receptors, leading to higher sensation of pain, but it’s possible to reactivate them using CBD.